An ImmTOR^TM-based approach to treating primary biliary cholangitis (PBC)

PBC is an autoimmune disorder in which the body mistakenly attacks the bile ducts leading to liver damage. To address this autoimmune disease, Selecta intends to coadminister ImmTOR with PDC-E2, the autoantigen implicated in PBC. The PDC-E2 antigen will be encapsulated in nanoparticles to minimize the systemic exposure of the antigen to a patient’s immune system. Patients with PBC are desperately in need of a targeted, liver-directed approach to treating the root cause of the disorder.

ImmTOR^TM is ideally suited to address PBC

Tolerogenic liver
sinusoidal
endothelial cells

Hepatic
regulatory
t cells

serum liver enzyme
in concanavalin
a Liver inflammation model

PBC is a T-cell liver disease driven by a well-defined antigen. ImmTOR has been shown in preclinical studies to induce a strong tolerogenic environment in the liver. Co-administration of ImmTOR with PDC-E2, the autoantigen implicated in PBC, has the potential to restore immune tolerance in the liver to directly address the precise cause of the disease. In addition, ImmTOR shows hepatoprotective properties in liver injury models demonstrating its unique ability to potentially treat liver-specific disorders like PBC.